Lobocrasol, a new diterpenoid from the soft coral Lobophytum crassum.
نویسندگان
چکیده
Lobocrasol (1), possessing an unprecedented diterpenoid skeleton, was isolated from the soft coral Lobophytum crassum. The structure of lobocrasol was established by extensive analysis of spectroscopic data.
منابع مشابه
Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum
Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with ...
متن کاملTetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
Three new cembranoids, culobophylins A-C (1-3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety wit...
متن کاملCembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A-C (1-3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1-4 were evaluated in vitro. Compound 4 exhibited cytotoxicity ...
متن کاملLobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum
Five new cembrane-type diterpenoids, lobocrassins A-E (1-5), were isolated from the soft coral Lobophytum crassum. The structures of cembranes 1-5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the ...
متن کاملAnti-Protozoal Activities of Cembrane-Type Diterpenes from Vietnamese Soft Corals.
Based on our previous finding that certain cembranoid diterpenes possess selective toxicity against protozoan pathogens of tropical diseases such as Trypanosoma and Plasmodium, we have subjected a series of 34 cembranes isolated from soft corals living in the Vietnamese sea to an in vitro screening for anti-protozoal activity against Trypanosoma brucei rhodesiense (Tbr), T. cruzi (Tc), Leishman...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Organic letters
دوره 11 14 شماره
صفحات -
تاریخ انتشار 2009